Dear Researcher,
Are your current PTM panels capturing the full complexity of metabolic regulation and chromatin remodeling?
The post-translational modification (PTM) landscape is evolving rapidly—with lysine lactylation and O-GlcNAcylation emerging as central regulators of gene expression, chromatin structure, and disease progression.
Over the past three years, both modifications have gained significant attention across disciplines, from cancer metabolism to immune cell plasticity and neurodegeneration.
Spotlight on Recent Findings:
Lactylation: Since its discovery in
Nature (Zhang et al., 2019), over
250 studies have explored its role in macrophage polarization, tumor immunology, and epigenetic reprogramming.
O-GlcNAcylation: As a nutrient-sensitive, reversible PTM, O-GlcNAc plays a pivotal role in stress responses, Alzheimer's pathology, and metabolic regulation.
"Lysine lactylation represents a novel link between metabolism and gene expression." — Nature Reviews Molecular Cell Biology, 2023
Why This Matters Now:
Histone lactylation has been identified as a marker of metabolic adaptation in tumors.
O-GlcNAc-phosphorylation crosstalk is being targeted for drug development in CNS disorders.
Major conferences like AACR and ASMS now feature dedicated sessions on metabolic PTMs.
How Can We Help?
At MtoZ Biolabs, we've developed specialized workflows for targeted quantification and enrichment of both lactylation and O-GlcNAcylation analysis, optimized for low-abundance detection and site-specific precision.
If you are exploring metabolism, chromatin dynamics, or cell state transitions, our solutions provide critical insight into PTM-mediated regulation.